Hi Mark,
I can answer some of your questions on the MCF5221X.
Yes, this device has two I2C, whereas the MCF5222X has one. Also the MCF5221X Real Time Clock can be clocked externally because the RTC will get power from Vstby if the main power is shut down. Vstby will both retain the RAM state, and RTC in this case.
Other than those items, plus memory size and price point, the two devices are very similar.
I will check into users manual items you mentioned.
Thanks very much for your feedback!
macl