Hi @tbtbtbt ,
You need to check your used low power mode, whether the I2C is working and the I2C module clock is working or not, this is very important, otherwise you will meet issues.
From the RT1020 reference, you can find:

Please also check, the following table in the RM:

So, you may need to use the OSC as the clock source, as the PLL3 is powered down, and you also need to clear MCR[DOZEN] bit in LPI2C module.
Wish it helps you!
Best Regards,
Kerry