Hi Amar, I hope you're doing well!
The choice of using I2C0 or I2C1 will depend mainly on which pins you are going to use in your design, as not every pin can be used for I2C0 or I2C1 functionality.
More information about this parts Pin Configuration can be found in chapter 7 of the QN908x's datasheet.
About Flexcomm, this is a peripheral which can be configured to work in some different modes, like USART, I2C, and SPI. Only Flexcomm 1 and 2 can be configured as I2C interfaces.
Please let me know if you need any more information.
Best regards,
Sebastián