Hi,
The MPX2010DP is designed to operate with positive pressure only (P1 > P2).
In other words the pressure applied to the P2 side should be lower than the pressure applied to the P1 side.
We do not recommend to use it at P1 < P2 even thought the device may work (negative output).
Only the MPXV70xx family is designed to measure a pressure that alternates from positive to negative (with an offset at 2.5V).
Best regards,
Tomas