Hi@Niuyanlin
Make sure that the clock source of LPTMR in low-power mode should be SIRC, and then disconnect the debugger before entering low-power mode
1. Process 4 shown in the following figure: How to understand switching from vlps to run
If it enters VLPS mode from run, then it is exit VLPS to RUN after waking up, not VPLS->VLPR->RUN
2. After the MCU is awakened, there is no need to initialize the clock (FIRC)
"STOP and VLPS mode exit sequence
Exit from a low-power stop mode is initiated either by a reset or an interrupt event. The following sequence then executes to restore the system to a run mode (RUN or VLPR):
1. The on-chip regulator in the PMC, clock generators and internal power switches are restored. This step is valid only for VLPS and not for STOP as in STOP mode the PMC is in Run regulation.
2. System and bus clocks are enabled to all masters and slaves.(so the answer is yes)
3. The CPU clock is enabled and the CPU begins servicing the reset or interrupt that initiated the exit from the low-power stop mode."