In one of our application i need to use this MCU with 100u Ohms shunt on positive side of the battery . When i tried the same with load , I am not getting the proper values of voltage and current . Please confirm.
No this is not possible!
The ISENSEL / ISENSEH can only measure GND referenced signals
The table below (from the datasheet) indicates the limitations / requirements for proper operation:
VINC is the voltage from ISENSEH to Gnd and from ISENSEL to Gnd
VIND is the differential voltage between ISENSEH and ISENSEL
Typically the IC/module GND point should be on the Shunt resistor either the "ISENSEH-side" or "ISENSEL-side".