Hello SANTHOSH_2902,
I hope all is great with you. Thank you for using the NXP communities.
Your design seems correct to me. I mean, in theory, the design might work as expected. But, in practice, there are a lot of factors that might affect the functionality.
In this case, I just want to add some comments:
- It would be helpful if you add the NXP device part numbers.
- Is your 8-channel multiplexer compatible with 5V supply? Are you supplying the rest of the device with 5V as well?

- Same comment with the I2C bus extender (U44), it is compatible with 5V?
- What is the supply voltage of the PCBA_2?
I am asking about the supply voltage to keep in mind that VIL, VOL, VIH and VOH are met for proper communication.
It is always recommended to move away the I2C bus from an EMI/EMC source such as motors.
I hope this information helps.
Regards,
David