Hi liuqimin,
1. No, you don't need to do other settings, except the selection of the correct COM port in config block and use the UART1 interface, PC6 pin for RX, and PC7 pin for TX, on the board.
2. To download the application to the board using the UART interface, you need to flash the NXP_MBDToolbox_S32K1xx\tools\BootLoader\RBF_Files\S32K144_Bootloader.rbf file over JTAG interface using the S32 Design Studio for ARM.
The procedure of flashing the boot loader algorithm is described in the Motor Control Class: Lecture 3 - Input Commands first video starting with 2.04 minute.