Hello @allmo
I have a few suggestions for external mode working.
If your Simulink model is saved as .mdl, try to save it as .slx and then run external mode again.
Also, I recommend to set a specific fixed step-size in the solver configuration for your model.

Make sure that the COM port associated with your board is not open or used by another process. Otherwise, your board cannot send data to Simulink.
Also, make sure that the sensor you are using is sending data to your board. The communication between Simulink and the board might be cut off because the board might be stuck in an I2C call function waiting for the data from the slave device.
If your are trying just to visualize the data your are receiving, you can use FreeMaster tool which is supported by our toolbox. The FreeMaster blocks can be found in the Utility Blocks from NXP Model-Based Design Toolbox for i.MX RT MCUs in Simulink Library Browser.
Best regards,
Stefan