Subject basically says it all. I'm using a SEGGER J-Link Pro on a custom RT1052 board (though I've also had this happen when connected with the J-Link to my RT1052 EVKB). My target has been freshly reset, and MCUX has either been running for a little bit, or has been freshly restarted (I've had both fail on me). I click the green bug to start my debug session, the SEGGER flash window comes up, compares the contents, they match so there's no programming to do, the IDE starts going through its usual "initializing the debug session" mechanics, then this error dialog pops up:
Error in final launch sequence:
Failed to execute MI command:
-file-exec-and-symbols C:/NXP/workspace/[redacted]/Debug/[redacted].axf
Error message from debugger back end:
Truncated register 0 in remote 'g' packet
Failed to execute MI command:
-file-exec-and-symbols C:/NXP/workspace/[redacted]/Debug/[redacted].axf
Error message from debugger back end:
Truncated register 0 in remote 'g' packet
Truncated register 0 in remote 'g' packet

Or hey, after deleting my breakpoints and trying again, I get a different message:
Error in final launch sequence:
Failed to execute MI command:
-file-exec-and-symbols C:/NXP/workspace/[redacted]/Debug/[redacted].axf
Error message from debugger back end:
Reply contains invalid hex digit 79
Failed to execute MI command:
-file-exec-and-symbols C:/NXP/workspace/[redacted]/Debug/[redacted].axf
Error message from debugger back end:
Reply contains invalid hex digit 79
Reply contains invalid hex digit 79

This issue is not unique to MCUX 11.0.1; I've been experiencing this type of failure randomly ever since I started work on the RT1050 platform. There doesn't appear to be a 100% reliable way to prevent the issue from occurring the next time I try to launch a debug session; I just have to pray that I don't waste another 20-30 seconds launching a debug session that fails before I have a chance to reach main().
And yes, sometimes the debug session launches just fine (so my debug pod and hardware are intact). Sometimes killing and restarting MCUX seems to fix things, but not always. It's just incredibly frustrating to have such a core feature be so unreliable.
David R.