Are you trying to debug a project which you have already debugged using the LPC-Link2 with CMSIS-DAP firmware? If so, you probably still have the launch configuration inside the project that is configuring debug to look for the CMSIS-DAP probe.
Try deleting the .launch files in the project, or else MCUXpresso IDE v10.1 allow you to press SHIFT at the same time as click on the QuickStart Panel's Debug button to force a full probe rediscovery.
For more information, please see chapter 3, "Debug Solutions Overview" of the MCUXpresso IDE v10.1 User Guide.
Regards,
MCUXpresso IDE Support