Hello ,
Hope you are doing well.
To answer your questions:
1- If I understood correctly, we can't debug once secure boot is enabled, therefore we can't talk about secure debug too ?
Not necessarily, you can access the secure part of the device with the debugger if a debug authentication method is implemented. Please review the details of this in section 51.7 Debug Authentication.

2- I don't know how secure boot ROM it works because i don't have access, but in this sense can you confirm that the ROM code doesn't enable TZEN for SB security features ?
For information regarding the secure boot, you can refer to AN12283. Could you please specify what you mean by TZEN?
3- Last question but not least, in your SDK last release you provide TFM implementation ? Can you please explain the perspectives of this implem and the eventual use cases ?
The examples we provide are designed to help our customer's get started with their applications using Trusted Firmware - M. For more information about the usage and applications I recommend to check the links provided in the following webpage. Here you will find the information of how TF-M works.
Hope it helps!
Sabina
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