Hi, Raymond,
As you know that the LPC17xx uses internal clock (IRC) after Reset and run application code based on IRC. If your application code switches to external OSC and use external OSC as cclk by either using PLL or not. Once the external OSC stops oscillating, the cpu will stop, all chip will stop, you can not enter interrupt, because there is neither interrupt vector for the external OSC module nor code running.

Hope it can help you
BR
XiangJun Rong