Hi, Visweshwar Srinivasan,
As you know that the interrupt pin is designed to connect to a hardware button in general, when user press a button, an interrupt is triggered. The hardware button is a mechanical component, the button logic signal will have bouncing/stable/bouncing waveform, so the interrupt circuit is designed to have a long delay to wait for the signal stable. So it is okay to have 280ms delay for the pin interrupt.
Regarding your second question, as you know that there is a Sample/Hold(S/H) circuit, which is a capacitor, in SAMPLE phase, external circuit charges the capacitor, in HOLD phase, the capacitor voltage keeps it's value, so analog channel input impedance varies with SAMPLE phase and HOLD phase, because the high speed ADC sampling frequency is very very high, the sample time is very short, the impedance in sample phase is very low, the analog channel variable input impedance can lead to the signal distortion because the external signal can not be treated as a voltage source.
I suggest you use an analog buffer based on operation amplifier to reduce the signal impedance.
Hope it can help you
BR
Xiangjun Rong