Hi, Yoram,
For another board TWR-LCD, I have downloaded the user manual of the board. From it's description, it supports External Bus Interface or SPI, I think you can use SPI port to transfer image data between LCD and MCU, but we have to consider the data load.
We can estimate the data load for the LCD:
(data load per second)=(frame rate per second)*X*Y*(bits per pixel). General, the frame rate is 65 frame/per second, assume the LCD is 480*272, Bits per pixel is 24. The data load will be 65*480*272*24=203MBPS, it is huge, that is why we suggest user uses FlexBus to transfer data. If you use SPI, obviously, the LCD can not update as 65 frame per second, you can set the the parameter of the SSD1289 so that it refresh very slowly.
BR
Xiangjun Rong