For what it's worth, I tend to use "Debug" anyway. However, on my K22F board, I have difficulty getting it to run without actually being in the debugger. When I download flash, or disconnect, the board never runs. I have to manually press reset. While I can work with this, at least for now, it is not behavior I am accustomed to. With any Atmel development I have done, when I download code or stop debugging, the processor always resets and begins normal execution of code.
Perhaps I am missing something? I guess I could try Erich's trick and create a debug config and make it work that way.