Hello BobMac,
Yes, you can run simulation on a S19 file using CodeWarrior debugger.
1) run the debugger in simulation mode (menu "Component" -> "Set Connection..." ->" Connection: Full Chip Simulation")
2) select appropriate MCU derivative in the debugger
3) Load s19 file (menu "File" -> "Load Application..." -> select "Motorola S-Record..." as a File Type), uncheck option "Run after successful load", select your S19 file and press button "Load Code.
In the assembly window you should see .S19 file code.
Stanish